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Denis R St Laurent Selected Research

carbazole

4/2005Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.
3/2004Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model.

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Denis R St Laurent Research Topics

Disease

2Infections
03/2014 - 10/2012
2Neoplasms (Cancer)
04/2005 - 03/2004
1Lewis Lung Carcinoma
04/2005
1Carcinoma (Carcinomatosis)
03/2004

Drug/Important Bio-Agent (IBA)

2carbazoleIBA
04/2005 - 03/2004
1Protease Inhibitors (Protease Inhibitor)IBA
03/2014
1asunaprevirIBA
03/2014
1daclatasvirIBA
10/2012
1BMS 250749IBA
04/2005
1Irinotecan (Camptosar)FDA LinkGeneric
04/2005
1Pharmaceutical PreparationsIBA
04/2005
13,9- difluoro- 12,13- dihydro- 13- (6- aminoglucopyranosyl)- 5H,13H- benzo(b)thienyl(2,3- a)pyrrolo(3,4- c)carbazole- 5,7(6H)- dioneIBA
03/2004